This list is judged on the stats and all around usefulness of the fully upgraded weapon. I’m not going to take infinite ammo into consideration, so no Infinite rocket launcher.
While not the strongest machine gun available, the SIG is probably the best. With a clip of 80 rounds, and a 1.5 second reload speed, this gun is the perfect weapon if used in conjunction with a shotgun wielding partner.
The first magnum you find is arguably the best. While not the fastest reload, this is the magnum with the largest clip, allowing you to carry much needed other items or more ammunition.
With a pretty small clip, and a 3 second reload time, how could this weapon make it into the list? Stopping power. This shotgun is perfect for getting up close and personal with whomever you may be fighting.
Why did this weapon get the number 2 slot of this list? Upgradeable scope. Combine that with a relativity short reload time and the guns semi-auto functionality and you have a perfect killing machine.
And the number 1 weapon in resident evil 5 is…
The…starting…pistol? How did this pitiful weapon take the first slo- Wait, a 100 bullet clip? The best critical chance in the game? Ammo is most commonly available? Oh. Well that seems like a perfect weapon to me.